| Children |
| | 1. James HEPBURN d. 1525 |
| | 2. John HEPBURN d. 1522 |
| | 3. Adam HEPBURN, of Crags, b. 1450, Hailes, Prestonkirk, East Lothian Sco d. Yes, date unknown |
| | 4. Patrick HEPBURN, 1st Earl Bothwell, b. 1453, Hailes, Midlothian, Scotland d. 18 Oct 1508, Bothwell, Lanarkshire, Scotland (Age 55 years) |
| | 5. George HEPBURN, b. 1454, Prestonkirk, East Lothian, Scotland d. 9 Sep 1513, of Bothwell, Lanark, Scotland (Age 59 years) |
| | 6. Elizabeth Agnes HEPBURN, b. 1461, Hailes, Midlothian, Scotland d. Berwickshire, Scotland  |
| | 7. Helen HEPBURN, b. 1463, Bothwell, Lanarkshire, Scotland d. Bothwell, Lanarkshire, Scotland  |
| | 8. Margaret HEPBURNE, b. 1469, Hailes, Midlothian, Scotland d. 8 Nov 1542, Bothwell, South Lanarkshire, United Kingdom (Age 73 years) |
| | 9. Agnes HEPBURN, b. Abt 1475, Whitsome, Berwick, Scot. d. Aft 03 Feb 1509/1510 (Age > 35 years) |
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